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KMID : 0984919990010010022
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Journal of Skin Barrier Research
1999 Volume.1 No. 1 p.22 ~ p.28
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Morphologic Characteristics of Skin Barrier and Stratum Corneum
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Ahn Sung-Ku
Hwang Sang-Min
Choi Eung-Ho
Lee Won-Soo
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Abstract
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The epidermis is formed from many layers of closely packed cells, the most superficial of which are flattened and filled with keratin. Horny cells are flat polyhedral-shaped non-uncleated cells, approximately 40㎛ in diameter and 0.5㎛ tick.
The corneocytes are cell remnants of the terminally differentiated keratinocytes. Their cellular organelles and cytoplasm have disappeared druing the process of cornification. The stratum corneum prevents loss of interstitial fluid from inside,
and prevents the penetration of harmful substances from outside. The barrier function is impaired when the horny layer is removed, experimentally by successive stripping with adhesive tape, or chemically by injury.
It was confirmed that the barrieris located in the stratum corneum and intercellular lipids play a key role in the establimshment of the barrier. Three stratum corneum lipids, ceramides, cholesterol and free fatty acids are required for
permeability barrier homeostasis. Intercellular lipid is primarily generated from the exocytosis of lamellar bodies during terminal differentiation. It is required for a competent skin barrier and forms the only continuous domain in the stratum corneum. In this article, the morphologic characteristics of the skin barrier and variable morphologic methods are introduced.
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KEYWORD
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Skin barrier, stratum corneum, morphology
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